Publications by authors named "E Porreca"
Article Synopsis
- Amyloidosis is a systemic disease where insoluble protein aggregates damage organs, particularly the heart, resulting in a condition known as cardiac amyloidosis (CA).
- The two main proteins involved in CA are transthyretin and misfolded immunoglobulin light chains, leading to different forms: transthyretin amyloidosis (ATTR-CA) and light-chain amyloidosis (AL-CA).
- Early detection is important for CA as it can lead to serious heart complications, and cardiovascular magnetic resonance imaging is highlighted as a useful tool for identifying it early.
Article Synopsis
- Amyloidosis is a systemic disease caused by the buildup of low molecular weight proteins in the body's tissues, adversely affecting various organs, particularly the heart.
- Cardiac amyloidosis (CA) is linked to poor outcomes, with the majority being light chain amyloidosis (AL-CA) and transthyretin amyloidosis (ATTR), which can further be classified into wild type (ATTRwt) and hereditary (ATTRh-CA).
- Early diagnosis of CA, especially regarding atrial involvement, is crucial for effective treatment, as new diagnostic techniques like advanced echocardiography and cardiac MRI can improve patient prognosis and survival rates significantly.
Background: Guidelines suggest indefinite anticoagulation after unprovoked venous thromboembolism (VTE) unless the bleeding risk is high, yet there is no consistent guidance on assessing bleeding risk.
Objectives: This study aimed to evaluate the performance of 5 bleeding risk tools (RIETE, VTE-BLEED, CHAP, VTE-PREDICT, and ABC-Bleeding).
Methods: PLATO-VTE, a prospective cohort study, included patients aged ≥40 years with a first unprovoked VTE.
Cardiac amyloidosis represents a spectrum of conditions characterized by the accumulation of insoluble fibrils, resulting in progressive deposition and myocardial dysfunction. The exact mechanisms contributing to the heightened risk of thromboembolic events and bleeding tendencies in cardiac amyloidosis remain unclear. Proteins such as transthyretin in transthyretin amyloidosis and light chains in light-chain amyloidosis, along with acute phase proteins in amyloid A (AA) amyloidosis, play complex roles in the coagulation cascade, affecting both coagulation initiation and fibrinolysis regulation.
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- Venous thromboembolism (VTE) significantly impacts cancer patients' health but education and awareness about it are severely lacking, with 63.5% of surveyed patients receiving inadequate information.
- A study of 2262 cancer patients from 42 countries revealed that many felt unprepared to recognize VTE risks, with only 67.8% receiving guidance on seeking medical help when needed.
- The research highlights critical gaps in VTE education and support, emphasizing the need for improved patient-centered care in managing cancer-associated VTE risks.