[The role of lymphocytes and secrete cytokines in autoimmune thyroid diseases].

Grave's disease and autoimmune hypothyroidism represent the two main autoimmune thyroid diseases, where an immune response is directed against the thyroid gland. The essence of these diseases is loss of tolerance of own tissues caused by malfunction of the T lymphocytes, which effect the production of antibodies reacting with particular cell structures and tissues. Cytokines participate in the induction and effector phase of the immune and inflammatory response and therefore play a critical role in the development of autoimmune thyroid diseases.

Heterogeneity of cytoplasmic and nuclear shape of lymphocytes during progression of chronic lymphocytic leukemia.

Peripheral blood from ten healthy subjects and from 44 patients at stages 0, I, II, III, IV of chronic lymphocytic leukemia (CLL), type B, was routinely smeared, fixed and stained by the May-Grunwald-Giemsa method. Fourier analysis of nuclear and cytoplasmic shape of smeared lymphocytes was carried out for the range 1-20 of harmonics (describing the pattern of contour folding in quantitative terms). In addition the roughness coefficients (describing the summarized measure of contour folding of an individual cell) were calculated and computer evaluated.