Publications by authors named "E Plas"
Background: Survivors of pediatric acute lymphoblastic leukemia (ALL) exhibit abnormal neurocognitive outcomes that are possibly due to exposures to neurotoxic chemotherapy agents. This study aimed to determine the feasibility of characterizing long-term neuroanatomical changes with neuroimaging in a preclinical model of treatment for ALL.
Methods: Female mice (C57BL/6) were randomly assigned to a saline control group (n=10) or a treatment group (n=10) that received intrathecal methotrexate and oral dexamethasone (IT-MTX + DEX).
Pediatric heart failure and transplantation carry associated risks for kidney failure and potential need for kidney transplant following pediatric heart transplantation (KT/pHT). This retrospective, United Network of Organ Sharing study of 10,030 pediatric heart transplants (pHTs) from 1987 to 2020 aimed to determine the incidence of waitlisting for and completion of KT/pHT, risk factors for KT/pHT, and risk factors for nonreceipt of a KT/pHT. Among pHT recipients, 3.
View Article and Find Full Text PDFBackground: Prevalence and risk of poor psychological outcomes following rhabdomyosarcoma (RMS) are not well-established.
Methods: Participants in this cross-sectional, case-control study (n = 713 survivors, 42.5% female; mean [SD] age, 30.
Background: Chronic kidney disease (CKD) is a relatively rare childhood disease that is associated with a wide array of medical comorbidities. Roughly half of all pediatric patients acquire CKD due to congenital anomalies of the kidneys and urinary tract, and of those with congenital disease, 50% will progress to end-stage kidney disease (ESKD) necessitating a kidney transplantation. The medical sequelae of advanced CKD/ESKD improve dramatically following successful kidney transplantation; however, the impact of kidney transplantation on neurocognition in children is less clear.
View Article and Find Full Text PDFArticle Synopsis
- Myotonic dystrophy type 1 (DM1) leads to neuromuscular degeneration, prompting a study to evaluate changes in white matter microstructure and cognitive/clinical abilities over three years in both DM1 patients and healthy adults.
- Declines in white matter were observed in DM1 patients, affecting various functional outcomes such as motor skills and intelligence, with some cognitive functions remaining stable.
- The research indicates that white matter health is crucial for understanding the progression of DM1, offering insights that could enhance the design of clinical trials aimed at treatment effectiveness.