Publications by authors named "E Pitera"
Background: The use of doxorubicin is associated with an increased risk of acute and long-term cardiomyopathy. Despite the constantly growing number of cancer survivors, little is known about the transcriptional mechanisms which progress in the time leading to a severe cardiac outcome. It is also unclear whether long-term transcriptomic alterations related to doxorubicin use are similar to transcriptomic patterns present in patients suffering from other cardiomyopathies.
View Article and Find Full Text PDFWhilst the survival rates of childhood acute lymphoblastic leukemia (ALL) have increased remarkably over the last decades, the therapy resistance and toxicity are still the major causes of treatment failure. It was shown that overexpression of heme oxygenase-1 (HO-1) promotes proliferation and chemoresistance of cancer cells. In humans, the HO-1 gene () expression is modulated by two polymorphisms in the promoter region: (GT)n-length polymorphism and single-nucleotide polymorphism (SNP) A(-413)T, with short GT repeat sequences and 413-A variants linked to an increased HO-1 inducibility.
View Article and Find Full Text PDFBackground: Clinical data suggest that BMI and gestational weight gain (GWG) are strongly interconnected phenotypes; however, the genetic basis of the latter is rather unclear. Here we aim to find genes and genetic variants which influence BMI and/or GWG.
Methods: We have genotyped 316 type 1 diabetics using Illumina Infinium Omni Express Exome-8 v1.
Article Synopsis
- - The study investigates the expression of a specific gene related to inflammation during Clostridium difficile infection (CDI), examining a group of 55 adults, including 27 CDI patients and 28 healthy individuals.
- - Results showed that CDI patients had higher white blood cell counts and C-reactive protein levels but lower albumin levels compared to healthy controls, indicating an inflammatory response.
- - The gene expression was significantly lower in CDI patients and inversely correlated with CRP levels, suggesting that reduced gene expression might indicate a weakened ability to combat the infection.
Background: BMI is a strong indicator of complications from type I diabetes, especially under intensive treatment.
Methods: We have genotyped 435 type 1 diabetics using Illumina Infinium Omni Express Exome-8 v1.4 arrays and performed mitoGWAS on BMI.