Novel Blood-Brain Barrier Shuttle Peptides Discovered through the Phage Display Method.

Delivery of therapeutic agents into the brain is a major challenge in central nervous system drug development. The blood-brain barrier (BBB) prevents access of biotherapeutics to their targets in the central nervous system and, therefore, prohibits the effective treatment of many neurological disorders. To find blood-brain barrier shuttle peptides that could target therapeutics to the brain, we applied a phage display technology on a primary endothelial rat cellular model.

Influence of the environment and occupational exposure on the occurrence of Q fever.

Q fever, which is caused by Coxiella bumetii, is a worldwide zoonotic infectious disease and ruminants are the main reservoir for human infections. Humans become infected primarily by inhaling aerosols that are contaminated with C. bumetii.

Potential association between Coxiella burnetii seroprevalence and selected risk factors among veterinary students in Slovakia.

The present study investigated the prevalence of antibodies to Coxiella burnetii and the possible factors predisposing students of veterinary medicine to C. burnetii infections. IgG antibodies to phase I and phase II C.

Serological study of Q fever in sheep in the territory of Eastern Slovakia.

Q fever is a zoonosis caused by infection with Coxiella burnetii. Although the reservoir of C. burnetii consists of various species, the most common sources of human infection are farm animals, such as cattle, goats, and sheep.

Prevalence of Coxiella burnetii antibodies in wild ruminants in Kavecany zoo, Kosice, eastern Slovakia.

Coxiella burnetii is an obligate intracellular agent that causes Q fever in humans and animals. The most important reservoirs of C. burnetii in nature are small wild rodents, but infection was also demonstrated in other animals, including ruminants.