Publications by authors named "E Piano Mortari"
Background: In early infected or severe coronavirus disease 2019 (COVID-19) patients, circulating NK cells are consistently reduced, despite being highly activated or exhausted. The aim of this paper was to establish whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein (SP) may directly trigger NK cells and through which receptor(s).
Methods: SP-stimulated human NK cells have been evaluated for the expression of activation markers, cytokine release, and cytotoxic activity, as well as for gene expression profiles and NF-kB phosphorylation, and they have been silenced with specific small interfering RNAs.
Article Synopsis
- The study investigates communication between the brain and immune cells, focusing on natural killer (NK) cells and innate lymphoid cells (ILC) 1 in the meningeal dura layer of adult mice.
- It reveals that interferon-γ and acetylcholine, produced by these immune cells, impact brain functions such as memory formation and anxiety-like behaviors by influencing neurotransmitter levels and synaptic connections.
- The findings highlight how immune-to-brain communication plays a vital role in regulating brain homeostasis and behavior under normal conditions.
Background: The contemporaneous presence of immune defects and heart diseases in patients with 22q11.2 deletion syndrome (22q11.3DS) might represent risk factors for severe coronavirus 2019 disease (COVID-19).
View Article and Find Full Text PDFHaploinsufficiency of A20 (HA20) is an inflammatory disease caused by mutations in the gene classically presenting with Behcet's-like disease. A20 acts as an inhibitor of inflammation through its effect on NF-kB pathway. Here we describe four consanguineous patients (three sisters and their mother) with a predominantly autoimmune phenotype, including thyroiditis, type I diabetes, hemolytic anemia and chronic polyarthritis.
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