Publications by authors named "E Peter Maziarz"
Article Synopsis
- EBV DNAemia surveillance is used to prevent post-transplant lymphoproliferative disorder (PTLD) in lung transplant recipients (LTRs), but its effectiveness in adult seropositive patients is unclear.
- A study analyzed EBV viral loads in seropositive LTRs and compared levels between those who developed PTLD and those who didn't, revealing that peak viral loads were only significantly higher after PTLD was suspected.
- The study found low positive predictive values (PPVs) for moderate (14.7%) and high-grade (33.3%) EBV DNAemia in indicating risk for future PTLD, suggesting improved diagnostic approaches are needed.
Article Synopsis
- Belatacept is used to prevent rejection in lung transplant patients, but the infection risks associated with its use haven't been thoroughly studied.
- A retrospective study analyzed infections in 52 lung transplant recipients treated with belatacept from 2011 to 2022, revealing significant rates of viral and bacterial infections, particularly cytomegalovirus (CMV).
- The findings highlight the need for collaborative research to further investigate infection risks and management strategies for lung transplant recipients receiving belatacept.
Background: Plasma microbial cell-free DNA (mcfDNA) sequencing can establish the etiology of multiple infectious syndromes by identifying microbial DNA in plasma. However, data are needed to define the clinical scenarios where this tool offers the highest clinical benefit.
Methods: We conducted a prospective multicenter observational study that evaluated the impact of plasma mcfDNA sequencing compared with usual care testing among adults with hematologic malignancies.
Article Synopsis
- - Researchers studied maribavir (MBV) to treat 15 cases of difficult-to-treat cytomegalovirus infections in 13 solid organ transplant patients.
- - Nearly half of the treatment episodes (47%) faced failure because of new MBV resistance or virus returning soon after stopping the medication.
- - On the positive side, 40% of the treatment episodes resulted in sustained viral clearance, meaning the virus was eliminated effectively.*