Publications by authors named "E Pesce"
Background: Although topical corticosteroids (TCS) represent first-line treatment for vulvar lichen sclerosus (VLS) and as such should be prescribed to all women at time of diagnosis, approximately 30% of patients do not experience complete symptom resolution following such treatment. TCS may not effectively improve vulvar trophism and elasticity, both of which are crucial for sexual function. Owing to its regenerative and healing properties, cord blood platelet-rich plasma (CB-PRP) may represent an efficacious supplementary therapy, to be administered following first line treatment with TCS.
View Article and Find Full Text PDFStudy Design: Retrospective analysis.
Objective: The aim of this study is to evaluate the functional outcomes and the health-related quality of life (HRQOL) in patients undergoing en bloc resection of spinal tumor.
Summary Of Background Data: En bloc resection in the spine is a surgical procedure designed to completely remove a tumor in one piece, with wide margins preserved, in order to reduce the risk of local recurrences.
Article Synopsis
- * Researchers investigated the G85E-CFTR variant using human nasal epithelial cells and found that the drugs elexacaftor and tezacaftor modestly improved CFTR function, but chronic treatment with ivacaftor had negative effects.
- * The study suggests that combining elexacaftor with a new corrector, ARN23765, can significantly enhance CFTR activity and highlights the need for better drug combinations to help patients with the G85E mutation.
There are many concerns about the impacts of Endocrine-Disrupting Chemicals on both wildlife and human populations. A plethora of chemicals have been shown to interfere with the Hypothalamic-Pituitary-Thyroid (HPT) axis in vertebrates. Disruption of the HPT axis is one of main endocrine criteria considered for the regulation of chemicals, along with the estrogen axis, androgen axis and steroidogenesis (EATS).
View Article and Find Full Text PDFHigh-throughput peptide array analysis and computational techniques for serological profiling of flavivirus infections: Implications for diagnostics and vaccine development.
J Med Virol
September 2024
Article Synopsis
- Arthropod-borne viruses like dengue virus (DENV) are a major global health issue, infecting around 400 million people annually and causing outbreaks even in non-endemic regions.
- The study aimed to improve serological diagnosis and identify new drugs by mapping immunogenic protein regions of DENV through high-density peptide arrays and computational methods.
- Twenty-four specific peptides were found that could distinguish DENV from other flaviviruses, with two peptides potentially serving as a serum biomarker for DENV infection, which may aid in developing diagnostic and preventative strategies.