Publications by authors named "E Perucca"
Background And Objectives: Aside from congenital malformations and impaired postnatal neurodevelopment, risks associated with antiseizure medication (ASM) use during pregnancy have been sparsely investigated, particularly outside of epilepsy. We aimed to assess these risks through a systematic literature review and meta-analysis, including ASM exposure for indication.
Methods: We searched MEDLINE, EMBASE, and Cochrane for studies including pregnant women on ASMs for any indication and untreated pregnant women, investigating obstetric complications and fetal/neonatal complications other than congenital malformations and impaired neurodevelopment.
Paternal exposure to antiseizure medications and offspring outcomes: a systematic review.
J Neurol Neurosurg Psychiatry
December 2024
Background: Concerns have recently been raised about risks to the fetus resulting from paternal exposure to antiseizure medications (ASMs). To address these concerns, we conducted a systematic review of the literature to assess neurodevelopmental and anatomical outcomes in offspring born to fathers taking ASMs at the time of conception.
Methods: Electronic searches of MEDLINE, PsycINFO, and Embase were conducted to identify human studies published in English that reported on outcomes, comprising neurodevelopmental disorders, major congenital malformations, small-for-gestational age or low birth weight, in offspring of fathers taking ASMs at conception.
Article Synopsis
- N-of-1 trials are single-patient studies that focus on individual responses to treatments, particularly useful for patients with rare forms of epilepsy where larger clinical trials are hard to conduct.
- A systematic review analyzed such trials to evaluate their design, outcomes, and biases, revealing strong individual treatment customization but also some reporting limitations.
- The findings highlight the potential of N-of-1 trials to provide valuable insights for treating epilepsy, suggesting a need for improved reporting and methodology in future studies.
Purpose: Prenatal exposure to antiseizure medications (ASMs) has been associated with an increased risk of major malformations and neurodevelopmental disorders, with the latter being mainly associated with valproate (VPA). Our aim was to compare neurocognitive outcome at age 6-7 years in children exposed prenatally to lamotrigine (LTG), carbamazepine (CBZ), valproate (VPA) or levetiracetam (LEV) monotherapy.
Methods: Eligible mother-child pairs were identified from the observational prospective multinational EURAP cohort study.