Publications by authors named "E Perivolioti"
Article Synopsis
- Novel molecular diagnostic tests, specifically T2 magnetic resonance (T2MR) assays, are being assessed for their effectiveness in quickly identifying pathogens in patients suspected of bacteraemia.
- In a study with 208 patients, T2MR assays reported results significantly faster than traditional blood culture methods, although they had some invalid report rates (6.73% for T2B, 9.9% for T2R).
- The T2MR assays demonstrated high negative predictive values, indicating their potential for quickly ruling out bacteraemia and aiding in better antimicrobial stewardship in intensive care settings.
The objectives of this study were to investigate the incidence of candidemia, as well as the factors associated with species distribution and fluconazole resistance, among patients admitted to the intensive care unit (ICU) during the COVID-19 pandemic, as compared to two pre-pandemic periods. All patients admitted to the ICU due to COVID-19 from March 2020 to October 2021, as well as during two pre-pandemic periods (2005-2008 and 2012-2015), who developed candidemia, were included. During the COVID-19 study period, the incidence of candidemia was 10.
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- Pyometra (P) can lead to serious health issues like sepsis and multiple organ dysfunction, which are identified through the role of Toll-like receptors (TLRs) in recognizing pathogens.
- A study was conducted on 200 female mice to evaluate the effects of TLR-7 and -9 via the MYD88 pathway and the NFκB response before and after ovariohysterectomy (RP), along with any lung injuries.
- Results showed significant changes in blood chemistry and immune responses, indicating that the immune system's reaction is tied to the TLR9-MYD88 pathway, marking a notable discovery in the localization and expression of TLRs and their role in lung injury related to pyometra.
Changes in hospitals' daily practice due to COVID-19 pandemic may have an impact on antimicrobial resistance (AMR). We aimed to assess this possible impact as captured by the Greek Electronic System for the Surveillance of Antimicrobial Resistance (WHONET-Greece). Routine susceptibility data of 17,837 Gram-negative and Gram-positive bacterial isolates from blood and respiratory specimens of hospitalized patients in nine COVID-19 tertiary hospitals were used in order to identify potential differences in AMR trends in the last three years, divided into two periods, January 2018-March 2020 and April 2020-March 2021.
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