Obesity, influenced by environmental pollutants, can lead to complex metabolic disruptions. This systematic review and meta-analysis examined the molecular mechanisms underlying metabolically abnormal obesity caused by exposure to a high-fat diet (HFD) and fine particulate matter (PM). Following the PRISMA guidelines, articles from 2019 to 2024 were gathered from Scopus, Web of Science, and PubMed, and a random-effects meta-analysis was performed, along with subgroup analyses and pathway enrichment analyses.
View Article and Find Full Text PDFRhizophora mangle's potential as a bioindicator of pollution trace metals (TM). TM in sediments, and leaves, stembark, and roots were evaluated. Absorbance was measured by an Atomic Absorption Spectrophotometer (AAS).
View Article and Find Full Text PDFAccurately characterizing permanent deformation in granular materials subjected to cyclic loading is crucial for pavement design. This paper introduces an alternative approach to characterizing permanent deformation in a framework that reduces the number of load cycle repetitions by applying an alternative analytical strategy based on plastic strain rate variation over time. The methodology uses a cycle-hardening approach to establish correlations between short-term (post-compaction) and long-term (shakedown state) plastic strain accumulation.
View Article and Find Full Text PDFLarge-scale syntheses of small molecules and kilo laboratories are crucial steps in drug development, especially in advanced stages. ()-5-((Benzhydrylsulfinyl)methyl)thiazole, ()-CE-123, a potent, selective, and novel atypical DAT inhibitor, has undergone iterative testing as part of the preclinical evaluation step. This required the process transfer, scale-up, and synthesis of a 1 kg preclinical batch.
View Article and Find Full Text PDFEnvironmental contaminants endanger human health and non-target organisms such as crocodiles (Crocodylus acutus) that live in aquatic bodies surrounding agricultural areas. Due to their intrinsic characteristics, these organisms could be bioaccumulating and transmitting organochlorine pesticides (OCs) to their eggs. The objectives of this study were to determine the OCs in infertile eggs of C.
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