Safety and efficacy of three alternative regimens against relapsing Plasmodium vivax malaria in glucose 6-phosphate dehydrogenase deficient patients in the Brazilian Amazon (ALTPRIM).

Background: Daily primaquine-induced hemolysis is a common cause of complications during Plasmodium vivax malaria treatment in individuals with glucose 6-phosphate dehydrogenase deficiency (G6PDd). Alternative regimens balancing safety and efficacy are needed.

Methods: G6PDd participants with P.

Public Health.

Background: High blood pressure (BP) level and variability has been linked to stroke, cerebral small vessel disease (CSVD), cognitive decline, and dementia. However, it is unclear whether sex/gender influences the association of BP level and variability with CSVD. Therefore, we aimed to examine sex-differences in the association of CSVD with 24-h BP level and variability.

Public Health.

Background: Cognitive impairment is associated with mortality. However, evidence using population-based studies is scarce, is limited to one cognitive assessment, and lacks the inclusion of non-fatal adverse health outcomes. Therefore, we aimed this study to (i) investigate the association of cognitive function with mortality and cardiovascular risk and (ii) determine whether cognitive tests improve the risk-stratification of endpoints beyond conventional risk factors.

MONITORING RESPIRATORY BIOMECHANICS, LUNG CAPACITY AND MOBILITY IN BARIATRIC SURGERY: PERIOPERATIVE ANALYSIS.

Background: Several preoperative pulmonary assessment protocols have been established over the years, but assessments of this magnitude are lacking in the bariatric population. Therefore, the assessment of lung capacity, maximum inspiratory and expiratory pressures, the peak expiratory flow and mobility can be predictors of operative safety and determine the time of hospital discharge.

Objective: To evaluate lung capacity, respiratory muscle strength and level of mobility in the pre, immediate post-operative and hospital discharge of patients undergoing bariatric surgery.

Dental appointments in the primary health care setting for users with toothache: a longitudinal analysis.

This study aimed to estimate the morbidity associated with toothache treated in the primary health care (PHC) setting, stratified by the population size of Brazilian municipalities, from 2018 to 2022. This longitudinal ecological study was based on public national data from routine public dental service utilization records within the Health Information System for Primary Care. These data were employed to compute the rate of dental appointments for users with toothache (per 1,000 users) within each municipality throughout 15 four-month periods (P1-2018 to P3-2022), classified by population size.