Publications by authors named "E Pella"
Purpose: Heart failure (HF) and atrial fibrillation (AF) are highly prevalent in hemodialysis. They are well-known significant modifiers of the disease associations with cardiovascular outcomes, but there is a lack of evidence regarding the effects of HF and AF on cardiorespiratory fitness. This study is the first to examine the possible association of the presence of HF and AF with exercise intolerance in patients undergoing hemodialysis.
View Article and Find Full Text PDFBackground: Risk prediction in haemodialysis (HD) patients is challenging due to the impact of the dialysis regime on the patient's volume status and the complex interplay with cardiac function, comorbidities and hypertension. Cardiac function as a key predictor of cardiovascular (CV) mortality in HD patients is challenging to assess in daily routine. Thus the aim of this study was to investigate the association of a novel, non-invasive relative index of systolic function with mortality and to assess its interplay with volume removal.
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- - This study examines how cardiorespiratory fitness differs in hemodialysis patients after 2-day versus 3-day interdialytic intervals, with findings showing that the longer interval (3 days) leads to worse fitness levels primarily due to fluid buildup.
- - Impaired cardiorespiratory fitness is a crucial predictor of mortality risks in hemodialysis patients, making this research vital as it focuses on a common issue faced by individuals receiving thrice-weekly hemodialysis.
- - The research involved 28 hemodialysis patients who undertook exercise testing, revealing that those tested after the 2-day interval had significantly better oxygen uptake values during peak exercise compared to those tested after 3 days. *
Article Synopsis
- - A meta-analysis was conducted to evaluate the impact of SGLT-2 inhibitors on heart failure (HF) events in chronic kidney disease (CKD) patients, revealing a 32% reduction in the risk of HF events compared to placebo.
- - The analysis included 12 randomized controlled trials with a total of 89,191 participants, showing that the effect of SGLT-2 inhibitors was more pronounced in patients with lower kidney function (eGFR <60 ml/min/1.73 m²).
- - The findings suggest that SGLT-2 inhibitors could play a significant role in preventing HF events in advanced CKD patients, potentially changing treatment approaches.
Article Synopsis
- * It regulates renal sodium reabsorption by influencing tubular sodium transporters associated with diuretics, suggesting its potential involvement in conditions like sodium-sensitive hypertension.
- * Recent research indicates that the relationship between uromodulin, sodium intake, and blood pressure is more intricate than previously thought, highlighting the need for a deeper understanding of its biological roles.