Publications by authors named "E Peju"
Article Synopsis
- A retrospective study conducted in a medical ICU from 2016 to 2020 examined cases of bloodstream infections (BSI) caused by Klebsiella pneumoniae, focusing on a hypervirulent strain (hvKP).
- Out of 70 patients with K. pneumoniae BSI, 9 (13%) were identified with hvKP, with a significant number (56%) having pneumonia as the cause of the infection.
- The study highlighted that a considerable portion of hvKP-BSI patients were homeless (56%), and while the 30-day mortality rate was high (44%), it did not significantly differ from that of classical Klebsiella pneumoniae BSI (cKP).
Article Synopsis
- Ventilator associated pneumonia (VAP) caused by wild-type AmpC-producing Enterobacterales is common in ICU patients, and the study explores the effectiveness of different antimicrobial therapies (AMT), specifically piperacillin ± tazobactam (PTZ) and third-generation cephalosporins (3GCs).
- In a study involving 274 ICU patients, no significant differences in treatment success at day 7 were found between the groups receiving PTZ, 3GCs, or other control treatments, with all groups showing success rates around 68-74%.
- However, patients treated with 3GCs had a higher likelihood of pneumonia recurrence by day 28 compared to those on PTZ
Article Synopsis
- Thrombocytopenia, defined as a low platelet count, is a frequent issue in ICU patients and is linked to poorer health outcomes, including higher mortality rates.
- A study involving 1166 ICU patients across 52 ICUs in 10 countries found that 43.2% had thrombocytopenia, with nearly one-quarter presenting with it upon admission.
- Thrombocytopenia at ICU admission was statistically associated with increased 90-day mortality, and while 22.6% of those affected received platelet transfusions, the majority were given as a precautionary measure.
Background: Except in a few retrospective studies mainly including patients under chemotherapy, information regarding the impact of immunosuppressive therapy on the prognosis of patients admitted to the intensive care unit (ICU) for septic shock is scarce. Accordingly, the PACIFIC study aimed to asses if immunosuppressive therapy is associated with an increased mortality in patients admitted to the ICU for septic shock.
Methods: This was a retrospective epidemiological multicentre study.