Publications by authors named "E Pastorello"
Purpose: Adaptive MRgRT by 1.5 T MR-linac requires independent verification of the plan-of-the-day by the primary TPS (Monaco) (M). Here we validated a Monte Carlo-based dose-check including the magnetostatic field, SciMoCa (S).
View Article and Find Full Text PDFRepeated HyperArc radiosurgery for recurrent intracranial metastases and dosimetric analysis of recurrence pattern to account for diffuse dose effect on microscopical disease.
Clin Transl Radiat Oncol
September 2024
Aims: Evaluate effectiveness and safety of multiple HyperArc courses and patterns of progression in patients affected by BMs with intracranial progression.
Methods: 56 patients were treated for 702 BMs with 197 (range 2-8) HyperArc courses in case of exclusive intracranial progression. Primary end-point was the overall survival (OS), secondary end-points were intracranial progression-free survival (iPFS), toxicity, local control (LC), neurological death (ND), and whole-brain RT (WBRT)-free survival.
Article Synopsis
- The study investigates how stereotactic body radiation therapy (SBRT) affects lymph-nodal prostate cancer oligometastases, focusing on the different treatment outcomes between pelvic and para-aortic lymph nodes.
- A total of 240 lymph-nodal oligometastases from 164 patients were analyzed, revealing a median progression-free survival (PFS) of 20 months for pelvic cases versus 11 months for para-aortic cases, although this difference wasn’t significant in further analyses.
- The findings indicate that while patients with para-aortic disease may have comparable PFS to those with pelvic disease, both groups demonstrate high local control rates, suggesting SBRT is beneficial for treating para-aortic metastases.
Background: Stereotactic radiotherapy (SRT) and Proton therapy (PT) are both options in the management of liver lesions. Limited clinical-dosimetric comparison are available. Moreover, dose-constraint routinely used in liver PT and SRT considers only the liver spared, while optimization strategies to limit the liver damaged are poorly reported.
View Article and Find Full Text PDFArticle Synopsis
- * The study involved 214 patients with noted hazelnut allergies, assessing their sensitization to specific hazelnut proteins (Cor a 1, Cor a 8, and Cor a 9) and found that those monosensitized to Cor a 8 had more severe allergic reactions compared to those sensitized to Cor a 1 or both proteins.
- * Results suggest that multiple sensitivities impact the severity of reactions, with patients who are only sensitized to Cor a 8 experiencing more frequent and intense system reactions than those with broader