Publications by authors named "E Parra-Peralbo"
Article Synopsis
- - Alopecia areata (AA) is an autoimmune condition that leads to hair loss, influenced by genetic and environmental factors, with recent studies suggesting that scalp microbiota may affect its progression through inflammatory responses.
- - A study with 24 participants analyzed the scalp microbiomes of those with varying severities of AA and healthy individuals, finding significant differences in microbial communities and their correlation with inflammation and AA severity.
- - Results showed that patients with severe AA had more pro-inflammatory bacteria, while those with milder forms had beneficial bacteria, indicating that scalp microbiota might be linked to AA inflammation, though further research is needed to understand the exact relationship.
Introduction: This scoping review explores the effectiveness of IL-1 pathway inhibitors in managing PSTPIP1-associated inflammatory diseases (PAID). These diseases are marked by abnormal IL-1 pathway activation due to genetic mutations.
Methods: Our methodology adhered to a pre-published protocol and involved a thorough search of MEDLINE and EMBASE databases up to February 2022, following the Joanna Briggs Institute Reviewer's Manual and the PRISMA Extension for Scoping Reviews.
Objectives: This research-on-research substudy uses a data-driven approach to investigate the range of appraisal tools in non-Cochrane systematic reviews and meta-analyses registered in the International Prospective Register of Systematic Reviews (PROSPERO).
Study Design And Setting: A comprehensive web scraping of all completed non-Cochrane registrations in PROSPERO from February 2011 to December 2017 was performed. The focus was classifying the appraisal tools based on study type, assessment aspects, and research topics.
Introduction: The Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway are known to be involved in inflammatory immune-mediated skin diseases, including psoriasis. The development of drugs targeting the JAK/STAT signaling pathway presents new treatment opportunities for psoriasis. However, the application of JAK inhibitors for the treatment of dermatological disorders is still in its early stages of development.
View Article and Find Full Text PDFOrigin and Development of the Adipose Tissue, a Key Organ in Physiology and Disease.
Front Cell Dev Biol
December 2021
Adipose tissue is a dynamic organ, well known for its function in energy storage and mobilization according to nutrient availability and body needs, in charge of keeping the energetic balance of the organism. During the last decades, adipose tissue has emerged as the largest endocrine organ in the human body, being able to secrete hormones as well as inflammatory molecules and having an important impact in multiple processes such as adipogenesis, metabolism and chronic inflammation. However, the cellular progenitors, development, homeostasis and metabolism of the different types of adipose tissue are not fully known.
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