Publications by authors named "E Papagianni"
Article Synopsis
- This study investigates rheumatoid arthritis-associated interstitial lung disease (RA-ILD) to understand how inflammation and lung injury occur, particularly through the role of neutrophil extracellular traps (NETs).
- It includes nine RA-ILD patients and nine healthy controls, measuring inflammatory markers and NET formation, as well as testing the effects of the medication nintedanib over 16 weeks.
- Results show that patients with RA-ILD have higher levels of certain inflammatory markers and NETs, and nintedanib treatment appears to reduce these markers, highlighting its potential effectiveness in managing the disease.
Article Synopsis
- Heart failure (HF) patients are especially at risk for respiratory infections, making pneumococcal and influenza vaccinations crucial to reduce health complications and hospital visits.
- Despite their importance, vaccination rates among HF patients are surprisingly low, prompting a review of the situation from 2005 to 2023 to understand coverage and its impact on health outcomes.
- The systematic review analyzed 23 studies involving over 6 million participants and found significant variability in vaccination rates, with flu coverage ranging from 2.5% to 97% and pneumococcal rates from 20% to 84.6%, while most studies indicated that vaccinations positively affected survival and hospitalizations.
Cannabidiol (CBD), a substance that belongs to the phytocannabinoids, appears to exert antioxidant, neuroprotective, antipsychotic, anticonvulsant, and anticancer properties. Recent evidence supports the immunoregulatory effect of CBD on autoimmune and/or inflammatory disease. Psoriasis is a chronic skin disease.
View Article and Find Full Text PDFThe clinical heterogeneity regarding the response profile of the antitumor necrosis factor (anti-TNF) in patients with Crohn's disease (CD) and psoriasis (PsO) is attributed, amongst others, to genetic factors that influence the regulatory mechanisms which orchestrate the inflammatory response. Here, we investigated the possible associations between the rs2910164 and rs767649 variants and the response to anti-TNF therapy in a Greek cohort of 103 CD and 100 PsO patients. We genotyped 103 CD patients and 100 PsO patients via the PCR-RFLP method, utilizing the de novo formation of a restriction site for the SacI enzyme considering the rs2910164, while Tsp45I was employed for the rs767649 variant.
View Article and Find Full Text PDFIntroduction The effects of incretin-based drugs, such as receptor agonists of glucagon-like peptide-1 and inhibitors of dipeptidyl peptidase-4, on bone metabolism are not completely clear yet. The aim of this study is to compare the effects of glucagon-like peptide-1 and inhibitors of dipeptidyl peptidase-4 on the bone to see how different elements of the incretin pathway affect bone quality in terms of biomechanical properties, bone turnover, and mineral properties. Materials and methods Forty 10-week-old Wistar rats were divided into four groups: a control group, a control diabetic group, a diabetic group treated with sitagliptin, and a diabetic group treated with exenatide.
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