Poly(curcumin-co-poly(ethylene glycol)) films provide neuroprotection following reactive oxygen species insult in vitro.

Curcumin is an antioxidant and anti-inflammatory molecule that may provide neuroprotection following central nervous system (CNS) injury. However, curcumin is hydrophobic, limiting its ability to be loaded and then released from biomaterials for neural applications. We previously developed polymers containing curcumin, and these polymers may be applied to neuronal devices or to neural injury to promote neuroprotection.

The inactivation of the Niemann Pick C1 cholesterol transporter restricts SARS-CoV-2 entry into host cells by decreasing ACE2 abundance at the plasma membrane.

Background: The Niemann Pick C1 (NPC1) protein is an intracellular cholesterol transporter located in the late endosome/lysosome (LE/Ly) that is involved in the mobilization of endocytosed cholesterol. Loss-of-function mutations in the NPC1 gene lead to the accumulation of cholesterol and sphingolipids in LE/Ly, resulting in severe fatal NPC1 disease. Cellular alterations associated with NPC1 inactivation affect both the integrity of lipid rafts and the endocytic pathway.

Treatment of the Temples: Brazilian Consensus.

Introduction: The temporal region is emblematic and challenging due to its structural and volumetric changes during aging, which significantly affect facial aesthetics. Despite the importance of addressing temporal aging, many injectors hesitate due to the region's anatomical complexity and risk of complications. This consensus aimed to provide expert guidance on the safest and most effective treatment strategies for the temple.