[Asthenic syndrome in general therapeutic practice].

The presented material indicates that asthenia can be considered as a universal protective mechanism accompanying various psychophysiological processes and somatic diseases, which are based on the mechanisms of energy deficiency. The article discusses different etiological factors and clinical forms of asthenic syndrome (AS) depending on the causes of its development. The research specifies the main effects of carnitine, according to which a conclusion is made about the possibility of use of L-carnitine preparations for the correction of AS in mono- and polytherapy.

[Oxidative stress in focal symptomatic and cryptogenic epilepsy in young patients].

Objective: To study oxidative stress in young patients with focal symptomatic and cryptogenic epilepsy and after the new-onset epileptic seizures.

Material And Methods: Patients, aged from 19 to 44 years, were distributed into three groups, 30 patients in each: patients after a few (first) epileptic seizures, patients in the clinical remission that has lasted at least one year, and patients with treatment-resistant epileptic seizures. The control group included 20 healthy people.

[Oxidative stress in epilepsy].

This article contains an analysis of clinical and experimental studies in which oxidative stress is considered as a possible mechanism in the pathogenesis of epilepsy. Oxidative stress occurs as a result of brain damage after epileptic seizures and may later cause epileptogenesis. Patients with epilepsy showed a high level of lipid peroxidation markers, while the activity of antioxidant defense system was low.

[Pharmacotherapy of endothelial dysfunction in patients with atherosclerotic brain ischemia].

We studied the effect of deproteinized hemoderivative of calf blood, thioctic acid and vinpocetine with piracetam on the endothelial function in patients with chronic cerebral ischemia stage III. After pharmacological treatment, there was the improvement in the endothelium properties of both large and small blood vessels. The index of occlusion that characterized the function of small vessels reached normal values while the phase shift did not approach to the reference values.

[Influence of the neural stem cell transplantation on the restoration of CNS functions in rats with cortical stroke].

Ischemic stroke was modeled in white pedigreeless rats by the superficial blood vessel devascularization in the sensorimotor cortex. The preparations of neural progenitors--rat embryonic neural stem cells (rENSC) and human olfactory epithelium-derived neural stem cells (hOENSC) and differentiated fibroblasts ("cell control") were transplanted at the perimeter of the devascularized region. These cells marked with vital tracer stayed alive in the brain parenchyma for at least 16 days.