Biocompatibility and biological activity of C fullerene adduct with L-threonine (C(CHNO)).

The aim of this work is to synthesise and study the biocompatibility and biological activity of the C fullerene adduct with l-threonine (C-Thr). The obtained adduct was identified using a complex of physicochemical methods, namely, C NMR spectroscopy, IR spectroscopy, thermogravimetric analysis, electron spectroscopy, elemental analysis, and high-performance liquid chromatography. The study of biocompatibility and biological activity of the C-Thr adduct included the study of haemocompatibility (haemolysis, platelet aggregation, plasma coagulation haemostasis, binding to human serum albumin, esterase activity), antiradical activity, cytotoxicity, cell proliferation, and interaction with DNA (determination of the DNA binding constant and genotoxicity).

[Gastroprotective properties of gefarnate analogs with oxygen atoms in alcohol chain].

We assessed the effects of some gefarnate analogs on gastric ulcer prophylaxis (adrenaline ulcers) and ulcer healing (acetic ulcers) and some secretory parameters in rats. Acute ulcers were induced in male Wistar rats by intraperitoneal injection of 2 mg/kg adrenaline hydrochloride. Rats were killed after 24 hours.

[Indirect electrochemical oxidation of blood plasma in combined treatment of patients with acute mediastinitis].

Treatment results in 61 patients with acute mediastinitis are analyzed. Combined treatment of acute mediastinitis, including cryoplasma-antienzymic complex use and indirect electrochemical blood plasma detoxication, promotes disappearance of microcirculation disorders, to earlier decreasing of endogenic intoxication, outcomes improvement.

[Selectivity of lysozyme oxidation by singlet oxygen].

Peptide analysis of tryptic hydrolysates of two lysozyme forms derived from oxidation of lysozyme with singlet oxygen shows that Trp-62, located at the active site, is destroyed. This is confirmed by the protective effect of the substrate (chitin), whose presense practically prevents the oxidation. A possibility of oxidating different tryptophan residues is discussed from the view-point of their availability to the reagent.