Publications by authors named "E P Parfent'eva"
Aim: To assess the relation between urinary excretion of profibrotic and antifibrotic growth factors, albuminuria and glomerular fibrosis in type 1 diabetic patients.
Materials And Methods: 64 patients with diabetes were examined, including 25 ones with normal albumin excretion rate (AER), 30 microalbuminuric and 9 macroalbuminuric patients. Urinary excretion of type IV collagen, transforming growth factor-beta 1] (TGF-beta 1), tumor necrosis factor-alpha (TNF-alpha), fibroblast growth factor-2 (FGF-2), hepatocyte growth factor (HGF) and bone morphogenetic protein-7 (BMP-7) was determined by ELISA and compared to control (10 healthy subjects).
[The pharmacological properties of the triterpenoids from birch bark].
Eksp Klin Farmakol
December 1993
Article Synopsis
- The birch bark was used to create a new triterpenic drug called betulenol and its derivative, diacetate.
- Tests on rats showed that these compounds exhibited beneficial effects, including lowering lipid levels, promoting bile flow, preventing kidney stones, and protecting liver health.
- The effectiveness of betulenol and diacetate was found to be greater than that of existing official drugs used for similar purposes.
Experiments on rabbits and white rats with experimental hyperlipidemia and atherosclerosis have shown that pentocyclic triterpenoids belonging to the alpha- and beta-amirin groups, of which saparal, glyciram and glycirenate are officinal drugs, are capable of reducing the level of cholesterol, beta-lipoproteins and triglycerides in the blood and that of cholesterol in aorta tissues. The effect of the compounds under study has been found to exceed the hypolipidemic action of the officinal antiatherosclerotic drugs, polysponine and cetamiphen, and to be noted for low toxicity. To screen hypolipidemic properties in the substances, an effective modification of experimental hyperlipidemia in rats has been offered.
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