Role of vascular endothelial growth factor in non‑small cell lung cancer pathogenesis.

Unlabelled: The angiogenesis is an important process in the pathogenesis of malignancies. It is regulated by various growth factors, with the vascular endothelial growth factor (VEGF) playing the central role. The aim of the present study was to evaluate possible associations of functional VEGF -2578C>A, -634G>C, and +936C>T polymorphisms with the risk for occurrence and progression of non-small cell lung cancer (NSCLC) in patients living in Republic of Belarus.

[Evaluation of connection of combinations of polymorphic variants of genes of xenobiotic metabolizing enzymes with a predisposition to lung cancer].

Imbalance between the phases of the biotransfotmation system (activation, detoxication and removal of toxic compounds) is one of the causes of multifactorial pathology developing. That is why study on the influence of the total contribution of polymorphic gene variants of xenobiotic biotransformation enzymes of all three phases on predisposition to lung cancer emergence is important. The aim of the work was to determine polymorphic variants of genes of xenobiotic biotransformation enzymes of lung cancer patients and to identify markers of predisposition to lung cancer.

[GST polymorphism and cytogenetic changes in lung tissues of lung cancer patients].

Carriers of GSTTI gene deletion were found to be more subjected to a risk of emerging non-small-cell lung cancer (NSLC) than those of normal GSTT1(+) genotype. Study on the relation between GST gene polymorphism and cytogenetic indices in lung cancer patients has shown a significant excess of the group average level in cells with micronuclei in NSLC patients with GSTTI(-). The frequency of cells with micronuclei was higher in smoking patients with a mutant genotype than in smoking carriers of the GSTT1(+) genotype.