Publications by authors named "E P Kovaleva"
Immunodeficiency conditions, which are characterized by reduced immune activity that promotes the development of chronic diseases, are needed for efficient monitoring. A promising area of monitoring and early diagnosis of immunodeficiency diseases is the determination of metabolic biomarkers in the blood. In this work, we identified a set of lipid biomarkers of immunodeficiency states by performing high-performance liquid chromatography-high-resolution mass spectrometry (HPLC-HRMS) analysis of blood plasma samples from mice and processing them with bioinformatics approaches.
View Article and Find Full Text PDFThe beneficial properties of probiotics have always been a point of interest. Probiotics play a major role in maintaining the health of Gastrointestinal Tract (GIT), a healthy digestive system is responsible for modulating all other functions of the body. The effectiveness of probiotics can be enhanced by formulating them with prebiotics the formulation thus formed is referred to as synbiotics.
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- The diagnosis of thyroid gland tumors is complicated, requiring specialized expertise and significant time, especially when analyzing many whole slide images from one patient.
- This paper explores using artificial intelligence, specifically a Multiple-Instance Learning model, trained on weak patient-level data from over 1100 patients to differentiate between benign and malignant cases, achieving a notable F1-Score of 0.85.
- The study highlights challenges in using real-world data, such as potential issues that could lead to model overfitting, and emphasizes that detailed annotations improve accuracy, especially in smaller datasets.
Background: Primary hyperparathyroidism (PHPT) is a endocrine disorder characterized by excessive secretion of parathyroid hormone (PTH) from parathyroid gland tumors. Parathyroidectomy (PTE) is the main treatment for PHPT, but it can lead to hypocalcemia in up to 46% of cases. Hypocalcemia is associated with seizures and life-threatening cardiac arrhythmias, and vitamin D deficiency can exacerbate PHPT severity and contribute to «hungry bones syndrome,» resulting in severe and persistent postoperative hypocalcemia.
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- Type 2 diabetes involves high blood sugar and reduced function of insulin-producing β-cells, prompting research into potential treatments.
- This study tested the effects of betulin, a natural compound from birch bark, on diabetic rats, focusing on various health parameters over a 28-day period.
- Results indicated that betulin improved blood sugar levels and reduced liver and kidney damage in diabetic rats while promoting the regeneration of β-cells, suggesting it could be a promising treatment for diabetes.