IgE antibody and resistance to infection. II. Effect of IgE suppression on the early and late skin reaction and resistance of rats to Schistosoma mansoni infection.

Most helminth parasites induce a strong IgE antibody and elevated eosinophil response in their mammalian hosts and a number of in vitro studies have suggested that IgE, possibly in association with eosinophils, may be an essential element of the host protective immunity against helminth infections. To assess the role of IgE in protective immunity, we examined the effect of suppressing the IgE antibody response on rat immunity to Schistosoma mansoni. Suppression was achieved in neonates by injections of rabbit anti-epsilon chain gamma-globulins, control rats received injections of unspecific gamma-globulins.

Frequency of glucose-6-phosphate dehydrogenase (G-6-PD) deficiency in Tanzanian males with typhoid fever.

The frequency of G-6-PD deficiency in the Dar es Salaam male population is given as 18.7%. In this preliminary study, is reported a frequency of 45% in males with typhoid fever--a figure more than twice the prevalence in the general Dar es Salaam male population.

Correlation of glucose-6-phosphate dehydrogenase (G-6-PD) deficiency and sickle cell trait (Hb-AS).

636 normal male blood donors were studied for haemoglobin genotype and G-6-PD deficiency. The results show that of 543 subjects with AA haemoglobin, 106 (19.5%) were G-6-PD deficient and of 93 individuals with AS haemoglobin 13 (14.