Zonal Characteristics of Collagen Ultrastructure and Responses to Mechanical Loading in Articular Cartilage.

The biomechanical properties of articular cartilage arise from a complex bioenvironment comprising hierarchically organised collagen networks within the extracellular matrix (ECM) that interact with the proteoglycan-rich interstitial fluid. This network features a depth-dependent fibril organisation across different zones. Understanding how collagen fibrils respond to external loading is key to elucidating the mechanisms behind lesion and managing degenerative conditions like osteoarthritis.

The interplay between ZigA and SltB promotes zinc homeostasis and cell envelope integrity.

is an opportunistic human pathogen that acquires nutrient metals from the vertebrate host amid infection. During zinc (Zn) scarcity, upregulates the expression of the predicted Zn metallochaperone, . Loss of compromises fitness during Zn deficiency, highlighting its role in this condition.

Police Contact, Sleep, and Mental Health in the Adolescent Brain Cognitive Development (ABCD) Study.

Using data from the Adolescent Brain Cognitive Development study (n = 3928), we examined how police contact relates to sleep problems, anxiety, and depressive symptoms during middle adolescence (M age = 14.09; SD = 0.68).

Impact of Heat and Mitigation Strategies on Healthcare Professionals: A Scoping Review.

Background: Rising global temperatures and increased use of personal protective equipment has led to increased risk of heat stress amongst healthcare professionals. This review synthesizes recent research on the impact of heat and heat mitigation strategies on healthcare professionals across disciplines and settings.

Method: Databases were systematically searched using keywords and data from included studies were extracted for content analysis.

Event-level differences in quantity, frequency, and consequences of cannabis use by modes of use: Moderation by differences in how often individuals use each mode among sexual minority women and gender diverse individuals.

Background: A handful of studies have examined differences in the subjective effects and consequences of utilizing different modes of cannabis (e.g., smoking vs.