[Glomerulopathy with fibrillary and tubular deposits].

The advent of up-to-date electron microscopes and molecular biological methods for the examination of renal puncture biopsies could define earlier undetectable and unworthy cellular structures and stromas. There is a diversity of diseases that can be diagnosed exclusively at the ultrastructural level, thus the literature has identified the concept of glomerular diseases with organized deposits. The current classifications based only on the ultrastructual deposits are imperfect as they fail to account for the etiological and pathogenetic features included in these diseases.

[Minimal-change glomerulonephritis in chronic lymphocytic leukemia: A clinical case].

Chronic lymphocytic leukemia (CLL) in association with glomerulonephritis (GN) and renal failure is a serious problem in terms of therapy. The paper reports a clinical case of a 64-year-old female patient with Binet stage C CLL accompanied by minimal-change GN complicated by nephrotic syndrome and the development of acute renal failure. GN was diagnosed on the basis of electron microscopic studies of renal biopsy specimens.

[Fibrillary glomerulonephritis and immunotactoid nephropathy: the current view of the pathomorphological substrate of disease].

Fibrillary glomerulonephritis (FGN) and immunotactoid nephropathy (ITN) are diseases diagnosed only by electron microscopy. Until recently, information on the diseases has reached as reports on some cases. Much information, including the authors' observations, has been presently gathered so as there is a chance of attempting to pool and analyze it.

[Modification of direct immunofluorescence assay to study paraffin-embedded renal and skin tissue sections].

Immunofluorescence assay has been widely used so far to diagnose glomerular and some skin diseases. The optimal antigen persistence is achieved using the frozen sections; however, their considerable shortcoming is the impossibility to long store preparations and to use a morphology archive. Our laboratory has modified a direct immunofluorescence study on paraffin-embedded renal and skin tissue sections, substantially increasing its accessibility.

[Fibrillary glomerulonephritis].

Fibrillary glomerulonephritis is a rare disease of unknown etiology and pathogenesis. In two thirds of cases, it is clinically manifested by the nephrotic syndrome resistant to cytostatic and corticosteroid therapy. Fibrillary glomerulonephritis is diagnosed by electronic microscopy and characterized by the presence of chaotically located fibrils with an average diameter of 18-22 nm in the deposits of immune complexes.