Publications by authors named "E P BENOIT"
Nicotinic acetylcholine receptors (nAChRs) are expressed in excitable and non-excitable cells of the organism. Extensive studies suggest that nAChR ligands have therapeutic potential, notably for neurological and psychiatric disorders. Organometallic ruthenium complexes are known to inhibit several medically important enzymes such as cholinesterases.
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- - Crotalphine, an analgesic peptide from South American rattlesnake venom, has a well-known pain-relieving effect, but its exact working mechanisms remain unclear.
- - Research focused on how crotalphine affects the Na1.7 channel, a target involved in pain sensation, using adult mouse neurons and various assays to assess effects on ion currents and cell viability.
- - Findings revealed that crotalphine can significantly inhibit Na current and impact cell viability, suggesting it may contribute to pain relief through the Na1.7 channel while also causing some cellular damage at higher concentrations.
Psilocybin has reemerged as a promising treatment for difficult-to-treat depression (DTD). Although there is limited evidence regarding interactions between psilocybin and other psychotropic drugs, clinical trials require that patients discontinue their antidepressants before study entry to isolate the benefits of psilocybin and to minimize the risk of adverse events. We present the first case of an adult patient with DTD who received psilocybin-assisted psychotherapy (PAP) in combination with two serotoninergic antidepressants (duloxetine and vortioxetine).
View Article and Find Full Text PDFRates of alcohol and/or substance use (ASU) among residents of predominantly Black and marginalized communities are similar to ASU rates in White communities. Yet ASU has worse consequences in predominantly Black and marginalized communities (e.g.
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