Association of Circulating Levels of Inflammatory Cytokines and Chemotherapy-Associated Subjective Cognitive Impairment in a South African Cohort of Breast Cancer Patients.

Background: The evidence links chemotherapy to cognitive impairment in breast cancer patients. This study assessed the link between subjective chemotherapy-related cognitive impairment and neuroinflammation in breast cancer patients.

Methods: In a correlational study, 113 patients aged 21 to 60 years on chemotherapy regimens completed the Functional Assessment of Cancer Therapy-Cognition Test (FACT-Cog) as a measure of subjective cognitive functioning at three time points (baseline- T, third cycle- T, and sixth cycle- T).

Effects of continuous nitrate treatment of hypolimnion in a small, hypereutrophic lake.

Continuous nitrate treatment is an innovative, nature-based and cost-effective restoration method that has been implemented in a small, hypereutrophic lake by redirecting the nitrate-rich waters of the lake's natural tributaries into its hypolimnion. The aim of this treatment is to increase the redox potential at the sediment-water interface in order to provide conditions for efficient phosphorus binding. To assess the effects of this treatment, studies of the physico-chemical and biological parameters of the lake waters were carried out before its application (PreNT - years 2005-2007), during its application (FullNT - 2008-July 2019), and in the period when installation was partly clogged (LimNT- August 2019-2021).

Effects of metformin on arterial elasticity and pro-inflammatory markers in black diabetes patients.

Background: Pro-inflammatory markers are linked with the development and progression of type 2 diabetes mellitus and arterial stiffening. Pulse Wave Velocity (PWV) and Augmentation Index (Aix) are non-invasive standard markers of arterial elasticity and predictors of cardiovascular mortality and morbidity.

Aim: To investigate the effects of metformin alone and in combination with glimepiride on arterial elasticity, pro-inflammatory cytokines in black type 2 diabetes mellitus patients.

Predispose, precipitate, perpetuate, and protect: how diet and the gut influence mental health in emerging adulthood.

Medicine often employs the 4Ps of , and factors to identify salient influences on illness states, and to help guide patient care. Mental illness is a significant cause of morbidity and mortality worldwide. Mental health is a complex combination of biological, psychological, environmental, and social factors.

Health-related quality of life among adolescents and young adults with mood and anxiety concerns.

Objectives: To characterize health related quality of life (HRQOL) for Canadians aged 16 to 25 (adolescents and young adults, AYAs) seeking care for mood and anxiety concerns at the First Episode Mood and Anxiety Program, in London, Ontario and to identify factors associated with HRQOL in this population.

Methods: AYAs completed demographic, psychometric, and HRQOL questionnaires. We calculated 36-Item Short-Form Health Survey (SF-36) scores standardized to Canadian and US population norms.