Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies.

To correlate levels of tumor-infiltrating lymphocytes (TIL) evaluated using the International Immuno-Oncology Biomarker Working Group methodology, and both density of tumor-infiltrating immune cell and clinicopathological features in different malignancies. 209 pathological samples from gastric cancer, cervical cancer (CC), non-small-lung cancer, cutaneous melanoma (CM) and glioblastoma were tested for TIL in hematoxylin eosin, and density of CD3, CD4, CD8, CD20, CD68 and CD163 cells by digital analysis. TIL levels were higher in invasive margin compartments (IMC).

Distribution of tumor-infiltrating immune cells in glioblastoma.

Aim: Evaluation of features related to infiltrating immune cell level in glioblastoma.

Methods: Tumor-infiltrating lymphocytes (TILs) through H&E staining, and TILs (CD3, CD4, CD8 and CD20) and macrophage (CD68 and CD163) levels through immunohistochemistry were evaluated through digital analysis.

Results: CD68 (9.

Impact of pathological features of brain metastases in prognosis.

Aim: To evaluate the prognostic value of tumor-infiltrating lymphocytes (TILs) and Ki67 in brain metastasis lesions, and the effect of adding them to variables of graded prognostic assessment score.

Patients & Methods: Clinicopathological information from 111 medical charts of brain metastasis patients was obtained, and TIL distribution (n = 84), Ki67 index (n = 79) and CD3 TIL (n = 64) were prospectively evaluated.

Results: Most frequent TIL pattern was perivascular (67.

MGMT promoter methylation in Peruvian patients with glioblastoma.

Purpose: O-methylguanine-DNA methyltransferase () promoter methylation predicts the outcome and response to alkylating chemotherapy in glioblastoma. The aim of this study is to evaluate the prevalence of methylation in Peruvian glioblastoma cases.

Patients And Methods: We evaluated retrospectively 50 cases of resected glioblastoma during the period 2008-2013 at Instituto Nacional de Enfermedades Neoplasicas in Peru.

Glioblastoma of pineal region: report of four cases and literature review.

We report four cases of glioblastoma in the pineal region. The patients presented a severe headache and vomiting. Brain imaging showed a heterogeneously enhanced tumor in the pineal region with obstructive hydrocephalus.