Publications by authors named "E Orchard"
Introduction: Cardiovascular disease is the commonest cause of death in Turner syndrome (TS) for which, arterial hypertension has a direct influence and is a key modifiable risk factor.
Objective: To investigate the prevalence and patterns of hypertension diagnosis and management in adult patients with TS who are registered in a large international multicentre database (TS-HTN study).
Methods: Retrospective multi-centre observational study of patients aged ≥18 years, included in the I-TS (International-TS) registry (2020-2022) utilising registry and participating centre collected data.
Background: On-scene improvised and interim decontamination protocols in the Initial Operational Response to chemical incidents aim for rapid intervention to minimise injury before specialist capabilities arrive. This study examines the effectiveness of UK improvised and interim protocols conducted in sequence.
Method: A simulant with methyl salicylate (MeS) in vegetable oil and a fluorophore was applied to participants' shoulders, arms and legs.
Article Synopsis
- The goal of computational psychiatry is to create models that connect differences in brain function to cognitive impairments and symptoms, which are often resistant to treatment.* -
- Research shows that to predict cognitive functioning accurately, large participant samples are needed, highlighting limitations in smaller patient studies.* -
- Using a transfer learning approach on neuroimaging data from the UK Biobank, the study found that predictions of cognitive functioning improved significantly, even with smaller sample sizes, validating the effectiveness of training models on larger datasets.*
Birthing a new maternal cognition literature: 10 recommendations for future research.
Arch Womens Ment Health
September 2024
Whilst the field of maternal cognition is gaining interest, with a recent increase in publications, there are still only a handful of existing studies. This presents a unique opportunity for reflection and growth, advancing scientific rigor to ensure that future interpretations of maternal cognitive functioning are based on robust, generalizable data. With this in mind, we offer ten recommendations for future cognitive research in motherhood, with a focus on intentional study design.
View Article and Find Full Text PDFBackground: Disruptions of axonal connectivity are thought to be a core pathophysiological feature of psychotic illness, but whether they are present early in the illness, prior to antipsychotic exposure, and whether they can predict clinical outcome remain unknown.
Methods: We acquired diffusion-weighted magnetic resonance images to map structural connectivity between each pair of 319 parcellated brain regions in 61 antipsychotic-naïve individuals with first-episode psychosis (15-25 years, 46% female) and a demographically matched sample of 27 control participants. Clinical follow-up data were also acquired in patients 3 and 12 months after the scan.