Redox-state-regulating enzymes have prognostic value in diabetic endometrial cancer patients: impact of statin use?

Objective: The incidence of endometrial cancer is increasing, and oxidative stress has been suggested to play a vital role in its carcinogenesis. Statins have an impact on the cellular redox-state. The aim of this study was to determine the effects of statin use on redox-state regulating enzymes in endometrial cancer in women with type 2 diabetes.

A David and Goliath set-up: a qualitative study of the challenges of ensuring the introduction of cost-effective new cancer medicines in Finland.

Background: To combat the global challenge of cancer, priority has been placed on the research and development of new cancer medicines (NCMs). NCMs are often approved for marketing in accelerated processes. Despite significant advances in treating cancer, the overall added value and high prices of NCMs has been questioned.

Snus and snus-like nicotine products moving across Nordic borders: Can laws protect young people?

Background: Use of snus and snus-like nicotine products is increasing, in particular among young people, in several Nordic countries and Estonia, while snus is legally on the market only in Sweden and Norway. Snus is available in a great variety of tastes and packaging particularly catering for young users. Recently, strong snus-resembling nicotine pouches have emerged on the market.

See you in court: obstacles to enforcing the ban on electronic cigarette flavours and marketing in Finland.

The aim of Finnish tobacco policy is to end the use of tobacco and other nicotine-containing products by 2030. Towards that end, the regulation of electronic cigarettes (e-cigarettes) in Finland is stricter than that in other European Union (EU) countries, including a ban on characterising flavours in e-cigarette liquids as well as on marketing e-cigarettes. This article describes the e-cigarette market, its regulation and the challenges faced in enforcing regulations in Finland.

Sequential adaptive elastic net approach for single-snapshot source localization.

This paper proposes efficient algorithms for accurate recovery of direction-of-arrivals (DoAs) of sources from single-snapshot measurements using compressed beamforming (CBF). In CBF, the conventional sensor array signal model is cast as an underdetermined complex-valued linear regression model and sparse signal recovery methods are used for solving the DoA finding problem. A complex-valued pathwise weighted elastic net (c-PW-WEN) algorithm is developed that finds solutions at the knots of penalty parameter values over a path (or grid) of elastic net (EN) tuning parameter values.