Analysis of factors influencing target PASI responses and side effects of methotrexate monotherapy in plaque psoriasis: a multicenter study of 1521 patients.

Methotrexate (MTX) is commonly used as first-line systemic treatment agent in psoriasis. We aimed to evaluate the clinical characteristics and treatment responses of patients with psoriasis undergoing MTX monotherapy. Data from adult patients with plaque psoriasis who received MTX monotherapy for at least 3 months between April 2012 and April 2022 were retrospectively evaluated in 19 tertiary care centers.

Real-life data over 36 weeks of guselkumab treatment in psoriasis patients: A single-center study from Turkey.

Background: Psoriasis is an important health problem responsible for morbidity and workforce loss. In recent years, anti-IL-23 drugs have become essential in psoriasis treatment.

Objectives: This study aimed to investigate the efficacy and safety of guselkumab therapy, recently used in Turkey, by examining real-life data over 36 weeks.

Quercetin-loaded sodium alginate/collagen/h-boron nitride potential wound dressings prepared using the Box-Behnken experimental design.

Background/aims: Natural and synthetic biocompatible polymers have received significant attention in the pharmaceutical industry due to their rapid and effective healing properties in the wound healing process. The aim of this study was to optimize the extraction of onions, the preparation of sodium alginate/collagen/hydrogen boron nitride (NaAlg/Col/h-BN) membranes using the Box-Behnken experimental design, and determine the optimal conditions for quercetin release. The study also aimed to investigate the antimicrobial and antioxidant activities of the prepared membranes and their therapeutic properties.

Tibial Tuberosity Rotation in Patients With Patellar Instability Versus Age- and Sex-Matched Controls.

Background: Several methods have been described to measure external rotation of the tibial tuberosity; all use femoral landmarks.

Purpose: To develop reproducible tibial-based methods to measure external rotation of the tibial tuberosity in patients with patellar instability.

Study Design: Cross-sectional study; Level of evidence, 3.

Clinical outcomes of COVID-19 in patients with chronic diseases.

Objective: This study was carried out to evaluate the clinical outcomes of patients having chronic diseases (CD) and COVID-19 infection.

Methods: The study was carried out retrospectively by including 1.516 patients with CDs who applied to two education and research hospitals between June 01, 2021, and August 01, 2021, and were diagnosed with COVID-19.