The role of OCT4 and CD44 in lower lip carcinogenesis.

Purpose: Carcinogenesis is characterized by the transformation of normal cells into malignant cells. Concerning the lower lip, exposure to UV radiation is the main etiological factor associated with the development of epidermoid carcinomas and actinic cheilitis. According to the hierarchical model theory, cancer development is driven by populations of cancer stem cells.

Thermogenic preworkout supplement induces alveolar bone loss in a rat model of tooth movement via RANK/RANKL/OPG pathway.

The aim of this study was to investigate the effect of thermogenic supplementation on the bone tissue of rats subjected to orthodontic movement. A total of 38 male Wistar rats underwent orthodontic movement of the left permanent maxillary first molars for 21 days. The rats were assigned to three groups: Control group: water; Thermogenic 1: C4 Beta Pump thermogenic; or Thermogenic 2: PRE-HD/Pre-workout.

Time-Course physiopathology of Envenomation in Swiss Webster Mice: Insights into Systemic Manifestations.

Objective: The expansion of human activities in northern Colombia has increased human-snake encounters, particularly with venomous . Given the limited knowledge of systemic envenomation effects and previous studies focusing only on early murine symptoms, this investigation aimed to describe the time-course physiopathology of envenomation following intramuscular injection .

Methods: Venom was inoculated in the gastrocnemius muscles of Swiss Webster mice, and blood, urine, and tissue samples were taken at different times to evaluate lethality and biochemical markers of renal function and oxidative stress.

Infrared spectroscopy of α-pinene ices irradiated by energetic ions at temperatures relevant to astronomical environments.

The effects of cosmic-ray bombardment of chiral molecules in the interstellar medium are simulated in the laboratory by performing radiolysis experiments of pure α-pinene ices at four different temperatures. The identification and significance of α-pinene have not been fully understood because of the insufficient amount of spectral information of these compounds at low temperatures. A comparison of the temperature dependence of the mid-infrared spectra of pure α-pinene ices before and after irradiation its irradiation by 61.

Sarcopenia in the Oldest-Old Adults in the Capital of Brazil: Prevalence and Its Associated Risk Factors.

Background: In light of the demographic context in which the older adult population is prominent, sarcopenia emerges as a significant concern for the health of these individuals.

Aim: To assess the frequency of sarcopenia and severe sarcopenia and the associated risk factors in the oldest adults living in the community.

Methods: There were 399 participants aged 80 or older, of both sexes, using primary health care services in the metropolitan area of Brasília, Brazil.