Publications by authors named "E O Tarasova"
This review focuses on the recently discovered specific action of two classical endocannabinoids (ECs), 2-arachidonoylglycerol (2-AG) and arachidonoyl ethanolamide (AEA), in the case of their synthesis and degradation in skeletal muscles; in other words, this review is dedicated to properties and action of the myoendocannabinoid (myoEC) pool. Influence of this pool is considered at three different levels: at the level of skeletal muscles, motor synapses, and also at the level of the whole organism, including central nervous system. Special attention is paid to the still significantly underestimated and intriguing ability of ECs to have positive effect on energy exchange and contractile activity of muscle fibers, as well as on transmitter secretion in motor synapses.
View Article and Find Full Text PDFArticle Synopsis
- Industrial multi-walled carbon nanotubes (ig-MWCNTs) are common carbon nanomaterials that people are likely to encounter, but their biodegradation by immune cells has not been thoroughly researched.
- This study examined how proinflammatory macrophages degrade two types of ig-MWCNTs, focusing on their behavior both inside and outside the cells.
- Results indicated that while ig-MWCNTs are significantly biodegraded by these cells, the mechanisms differ: intracellular nanotubes break down into graphene flakes, while extracellular nanotubes simply become thinner, highlighting the potential for developing nanomaterials with tailored biodegradation properties.
A novel convenient 2-step synthesis of substituted pyrido[1,2-]indoles is developed starting from easily available pyrylium tetrafluoroborates and -bromoanilines. A conversion of the pyrylium tetrafluoroborates to pyridinium ones followed by their palladium catalyzed intramolecular cyclization allows the formation of 24 examples of N-fused heterocycles. A one-pot two-stage cyclization procedure was developed.
View Article and Find Full Text PDFArticle Synopsis
- Researchers synthesized cellulose palmitates (CPs) using a catalyst-free method in a superbase ionic liquid environment, focusing on varying degrees of substitution (DS) influenced by temperature, time, and vinyl palmitate ratios.
- * The study detailed the effects of reaction conditions on CPs' structural composition, revealing the importance of specific hydroxy groups in the transesterification process and identifying optimal conditions that result in a DS between 0.5 to 2.3.
- * Various spectroscopic methods verified the CPs' chemical structure and stability, while comparisons of untreated and regenerated cellulose highlighted changes in their properties due to the ion liquid system used.
Circular Rep-encoding single-stranded DNA (CRESS-DNA) viruses encode for a Replicase (Rep) that is essential for viral replication. Rep is a helicase with three domains: an endonuclease, an oligomeric, and an ATPase domain (ED, OD, and AD). Our recent cryo-EM structure of the porcine circovirus 2 (PCV2) Rep provided the first structure of a CRESS-DNA Rep.
View Article and Find Full Text PDF