Publications by authors named "E O Hoogendijk"
Objective: To evaluate the effect of ferritin-guided donation intervals on haemoglobin (Hb) and ferritin levels, iron deficiency and low Hb deferrals in whole-blood donors.
Design: A cluster-randomized stepped-wedge trial.
Methods: In 2017-2019, Sanquin gradually implemented ferritin-guided donation intervals.
Short-term Frailty Index Fluctuations in Older Adults: Noise or Signal?
J Gerontol A Biol Sci Med Sci
December 2024
Background: Reversible short-term fluctuations in the frailty index (FI) are often thought of as representing only noise or error. Here, we assess (i) the size and source of short-term FI fluctuations, (ii) variation across sociodemographic characteristics, (iii) association with chronic diseases, (iv) correlation with age, frailty level, frailty change, and mortality, and (v) whether fluctuations reflect discrete health transitions.
Methods: Nationwide, biweekly longitudinal data from 426 community-dwelling older adults (70+) were collected in the FRequent health Assessment In Later life (FRAIL70+) study using a measurement burst design (5 122 repeated observations, median of 13 repeated observations per person).
Background: Obesity may affect an individual's immune response and subsequent risk of infection, such as a SARS-CoV-2 infection. It is less clear whether overweight and long-term obesity also constitute risk factors. We investigated the association between the degree and duration of overweight and obesity and SARS-CoV-2 infection.
View Article and Find Full Text PDFObjectives: Nonpharmacologic interventions (NPIs) constitute an important part of treatment for older adults, cover a broad and diverse range of interventions, and have advantages over pharmacologic interventions (eg, limited adverse side effects). However, an unambiguous definition of NPIs is still lacking. Defining NPIs may facilitate research on this topic and enhance comparability of results between studies, and might help to face the challenges of recognition, acceptation, funding, and implementation.
View Article and Find Full Text PDFArticle Synopsis
- - The increasing complexity of health issues among older adults makes it challenging for healthcare professionals to balance treatment benefits and risks, prompting a need for effective mortality prediction models.
- - This study systematically reviewed 22 studies with 38 unique mortality prediction models for community-dwelling seniors, finding that models based on frailty indices and machine learning demonstrated varying degrees of accuracy.
- - While some models performed well and showed potential for clinical use, there is a pressing need for standardized methodologies and further validation before widespread implementation.