Predictive modeling of adverse drug reactions to tamoxifen therapy for breast cancer on base of pharmacogenomic testing.

Objectives: The present study investigated the analysis of adverse drug reactions (ADRs) to tamoxifen (TAM) in breast cancer patients in relation to the carriage of genetic polymorphisms of genes encoding enzymes of CYP system and transporters of P-glycoprotein (Pg) and predictive models based on it.

Methods: A total of 120 women with breast cancer taking adjuvant TAM were examined for the gene polymorphisms such as , , , , , and (). Allelic variants were determined using the real-time polymerase chain reaction method.

[The problems of physicians-paramedical personnel interaction].

The problem of physicians-paramedical personnel interaction has long history. There are such reasons for misunderstanding as: actual stereotypes and arrogant attitude on the part of physicians, low assessment of medical nurse professional activities, gender inequality. The system of medical care becomes more complicated depending on advanced technologies, sophisticated specialization and disregard to human personality relations that complicates adaptation of specialists and team relationships.