Publications by authors named "E O Danchenko"
For antibody-based drugs, it is important and relevant to study their toxic effects, which can often become limiting when prescribing this type of therapy. General toxicity of antiviral drug Ergoferon based on technologically processed antibodies was studied on sexually mature animals. Analysis of acute toxicity showed the absence of lethal outcomes when the drug was administered to adult rats at the maximum tolerated doses.
View Article and Find Full Text PDFArticle Synopsis
- - A new method is introduced for measuring glycogen levels in tissues while keeping their structure intact, using iodine for staining.
- - This technique ensures that the results are not affected by other polysaccharides present, as they do not react with iodine but instead break down into reducing sugars during hydrolysis.
- - The quantification of glycogen is then derived from a calibration curve created for this staining process.
The authors report data demonstrating the in vitro influence of 0.3-6 per thousand ethyl alcohol on the results of determination of metabolic parameters, enzymatic activity, and certain hormones in the blood serum. It is shown that ethyl alcohol may change results of immunoenzyme assays used for kinetic determination of enzyme activities and metabolites.
View Article and Find Full Text PDF[Modulation by tauroursodeoxycholic acid of proliferation of the rat ischemic liver hepatocytes].
Vopr Med Khim
December 2001
The influence of the tauroursodeoxycholic acid (TUDCA) on hepatocyte proliferation after 180-minute ischemia of rat liver was investigated. TUDCA in a dose of 200 mg/kg did not change hepatocyte proliferation in the liver of intact rats and had no cytotoxic effect. The preliminary introduction of TUDCA accelerated regenerative processes in the liver in the postischemic period possibly due to synchronization of hepatocyte division.
View Article and Find Full Text PDF