Publications by authors named "E O Adewoye"
Alterations in plasma and erythrocyte membrane fatty acid composition following exposure to toxic copper level affect membrane deformability and fluidity in female wistar rats.
J Trace Elem Med Biol
December 2023
Background: Deformability and fluidity function of the red blood cell membrane are properties defined by the lipid composition. Toxic copper level induces membrane lipid peroxidation which could cause membrane instability. This study therefore investigated the effect of exposure to toxic copper level for 30 days on red blood cell membrane deformability and fluidity in female Wistar rats.
View Article and Find Full Text PDFArticle Synopsis
- Copper is essential for energy metabolism and red blood cell formation but can be harmful in excess, leading to oxidative damage and cellular disruption.
- In a study with male Wistar rats, one group received copper sulfate to induce toxicity while a control group received distilled water for comparison over 30 days.
- Results indicated that copper toxicity increased the activity of several key enzymes and levels of ATP and glutathione in red blood cells, while decreasing lactate dehydrogenase activity and nitric oxide levels, suggesting an altered metabolic response due to copper excess.
Objective: Women are more susceptible to both iron deficiency and copper toxicity due to monthly flow and estrogen action, respectively. Oral iron is beneficial for menstruating women and enhances erythropoiesis, but both deficiency and excess of copper impact iron absorption and mobilization. The aim of this study was to investigate the possibility of mitigating copper toxicity in female Wistar rats while supplementing with iron.
View Article and Find Full Text PDFObjective: Endogenous prostaglandins are involved in hemostasis, renal excretion of electrolytes, and implicated in dysmenorrhea. Piroxicam and Nitroglycerin are common drugs used in treating dysmenorrhea by inhibiting the cyclooxygenase pathway involved in prostaglandin production. However, studies comparing the effects of these drugs on prostaglandin-modulated hemostasis and renal function are lacking.
View Article and Find Full Text PDFObjective: During pregnancy, maternal exposure to ultraviolet radiation (UVR) has been linked to altered offspring immune and health status. This study was therefore designed to investigate some markers of immune response in the offspring of pregnant Wistar rats exposed to UVR at various points of gestation.
Methods: Thirty pregnant rats were divided into 6 groups (n=5) as follows; group I, control, consisting of pregnant rats unexposed to UVR.