Performance assessment of SD Bioline TB MPT64 assay for the diagnosis of complex in Lagos, Nigeria.

This study assessed the performance of SD Bioline MPT64 immunochromatographic test for the identification of complex (MTBC) in Nigeria.A total of 157 mycobacterial isolates, comprising 120 (76.4%) MTBC (, 112; , 5; , 3) and 37 (23.

Improving the Understanding of the Immunopathogenesis of Lymphopenia as a Correlate of SARS-CoV-2 Infection Risk and Disease Progression in African Patients: Protocol for a Cross-sectional Study.

Background: The COVID-19 pandemic, caused by SARS-CoV-2, continues to impact health systems throughout the world with serious medical challenges being imposed on many African countries like Nigeria. Although emerging studies have identified lymphopenia as a driver of cytokine storm, disease progression, and poor outcomes in infected patients, its immunopathogenesis, as well as environmental and genetic determinants, remain unclear. Understanding the interplay of these determinants in the context of lymphopenia and COVID-19 complications in patients in Africa may help with risk stratification and appropriate deployment of targeted treatment regimens with repurposed drugs to improve prognosis.

Draft Genomic Sequences of Three Escherichia coli Sequence Type 131 Isolates (H45, H43ii, and H43iii) from Patients in Lagos, Nigeria.

sequence type 131 (ST131) has recently emerged as a leading multidrug-resistant pathogen that causes urinary tract and bloodstream infections in humans. Here, we report the draft genomic sequences of three ST131 isolates, H45, H43ii, and H43iii, from urine samples of patients in Lagos, Nigeria.

Genome Analysis of Multidrug-Resistant Isolated from Poultry in Nigeria.

is one of the most common commensal bacteria of the gastrointestinal tract of humans and warm-blooded animals. Contaminated poultry can lead to disease outbreaks in consumers causing massive economic losses in the poultry industry. Additionally, commensal can harbor antibiotic resistance genes that can be transferred to other bacteria, including pathogens, in a colonized human host.

Plasmid Replicons and β-Lactamase-Encoding Genes of Multidrug-Resistant Isolated from Humans and Food Animals in Lagos, Southwest Nigeria.

As resistance to the β-lactam class of antibiotics has become a worldwide problem, multidrug-resistant (MDR) human ( = 243) and food animal ( = 211) isolates from Lagos, Nigeria were further tested to characterize β-lactamase-encoding genes and plasmid replicons. Four β-lactamase-encoding genes (, , , and ) were detected using PCR-based replicon typing, 13 and 17 different replicons were identified using a subset of MDR from humans ( = 48) and animals ( = 96), respectively. Replicon types FIB and X2 were detected in equal numbers (2/48; 4.