Publications by authors named "E O'Mara"
Article Synopsis
- The study explores the impact of violence exposure on anxiety and psychiatric disorders in adolescents, particularly focusing on how perceived safety and threat sensitivity may mediate these effects.
- A sample of 54 adolescents completed an online survey, revealing that perceived safety is linked to lower anxiety and threat sensitivity, while violence exposure itself did not show a significant connection.
- The results suggest that increasing perceived safety could protect against anxiety, with threat sensitivity serving as a key factor in this relationship, indicating a potential avenue for intervention.
Dysregulation of the endocannabinoid (eCB) system is implicated in various stress-related neuropsychiatric disorders (SRDs), including anxiety, depression, and post-traumatic stress disorder (PTSD). In this systematic review and meta-analysis, our objectives were to characterize circulating anandamide (AEA) and 2-arachidonoylglycerol (2-AG) concentrations at rest and in response to acute laboratory-based psychosocial stress in individuals with SRDs and without (controls). Our primary aims were to assess the effects of acute psychosocial stress on eCB concentrations in controls (Aim 1), compare baseline (prestress) eCB concentrations between individuals with SRDs and controls (Aim 2), and explore differential eCB responses to acute psychosocial stress in individuals with SRDs compared with controls (Aim 3).
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- The study examines how a specific genetic variant (FAAH C385A) affects anxiety and depression symptoms and brain responses in youth transitioning into adolescence.
- Results show that youth with the AA genotype experience lower depressive symptoms compared to other genotypes, but no significant differences were found for anxiety or neural responses.
- This research highlights the importance of the FAAH variant in understanding mental health risks during adolescence and suggests further studies to explore its broader implications in neurodevelopment.
PTC596 is a novel, orally bioavailable, small-molecule tubulin-binding agent that reduces B-cell-specific Moloney murine leukemia virus insertion site 1 activity and is being developed for the treatment of solid tumors. A phase 1, open-label, multiple-ascending-dose study was conducted to evaluate the pharmacokinetics and safety of the drug in subjects with advanced solid tumors. PTC596 was administered orally biweekly based on body weight.
View Article and Find Full Text PDFObjectives: In previous years, otherwise healthy infants with neonatal abstinence syndrome (NAS) in our hospital were transferred to the NICU and frequently treated with medication. Currently, infants with NAS room-in with their mothers and rarely require medication. We sought to understand the lived experience of nurses on maternity and well-newborn units caring for infants with NAS.
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