Publications by authors named "E Nunez-Delicado"

Ageing leads to a gradual deterioration of the organs, with the brain being particularly susceptible, often leading to neurodegeneration. This process includes well-known changes such as tau hyperphosphorylation and beta-amyloid deposition, which are commonly associated with neurodegenerative diseases but are also present in ageing. These structures are triggered by earlier cellular changes such as energy depletion and impaired protein synthesis, both of which are essential for cell function.

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Water pollution caused by dyes is a significant environmental issue, necessitating the development of effective, cost-efficient decolorization methods suitable for industrial use. In this study, a Chitosan-Fe polymeric gel was synthesized, characterized, and tested for removing the azo dye Direct Red 83:1 from water. The polymeric magnetic chitosan was analyzed using various techniques: Field Emission Scanning Electron Microscopy (FE-SEM) revealed a porous structure, Differential Scanning Calorimetry (DSC) and Thermal Gravimetric Analysis (TGA) demonstrated the thermal stability, Infrared Spectrophotometry (IR) indicated the successful coordination of iron at the C3 position, and X-ray Powder Diffraction (XRD) confirmed the crystalline nature of the polymeric structure.

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Article Synopsis
  • The SMN1 gene defect leads to spinal muscular atrophy (SMA), characterized by the loss of motor neurons and resulting muscle weakness and atrophy.
  • Current treatments improve symptoms but struggle to provide a permanent fix for the genetic issue behind SMA.
  • An innovative CRISPR-Cas9 approach was used to successfully correct the SMA mutation in mice, with long-term benefits observed when combined with additional genetic supplementation, offering hope for more effective treatments for inherited diseases.
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Article Synopsis
  • Scientists found a special treatment that helps cells change to a flexible state, which is important for healing injuries in muscles.
  • This treatment uses certain chemicals that help muscle cells heal better and faster, even in old mice.
  • The research suggests this method might be a good way to help with healing injuries and could be easier to use than changing genes.
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The significant environmental issue of water pollution caused by emerging contaminants underscores the imperative for developing novel cleanup methods that are efficient, economically viable, and that are intended to operate at high capacity and under continuous flows at the industrial scale. This study shows the results of the operational design to build a prototype for the retention at lab scale of pollutant residues in water by using as adsorbent material, insoluble polymers prepared by β-cyclodextrin and epichlorohydrin as a cross-linking agent. Laboratory in-batch tests were run to find out the adsorbent performances against furosemide and hydrochlorothiazide as pollutant models.

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