32P-post-labelling of 7-(3-chloro-2-hydroxypropyl)guanine in white blood cells of workers occupationally exposed to epichlorohydrin.

Epichlorohydrin (ECH) is a simple 3-carbon epoxide of industrial importance. It has been shown to be genotoxic in several systems and carcinogenic in experimental animals. The aim of the present investigation was to study DNA adducts of ECH as a biomarker of occupational exposure to this chemical.

On the dynamics of triadic synaptic arrangements: computer experiments with formal neural nets of chaotic units.

Computer simulations were carried out in an attempt to understand the possible operating modes of synaptic triadic arrangements as described in the dorsal lateral geniculate nucleus of the monkey. Small networks of "chaotic" units (piecewise linear internal maps) were used to investigate their performance as ON-gates for the transmission of spikes. "Chaotic" units have advantages over "logic" units because the former are asynchronous, it is possible to simulate temporal summation, and also to adjust subthreshold time-constants.