Publications by authors named "E Nishi"
Proteinuria, especially albuminuria, serves as an independent risk factor for progression in cardiovascular and renal diseases. Clinical and experimental studies have demonstrated that renal nerves contribute to renal dysfunction in arterial hypertension (AH). This study hypothesizes that renal nerves mediate the mechanisms of protein endocytosis by proximal tubule epithelial cells (PTEC) and glomerular function; with dysregulation of the renal nerves contributing to proteinuria in Wistar rats with renovascular hypertension (2-kidney, 1-clip model, 2K-1C).
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- * It involved 179 female patients and used a decision tree model to analyze data including dementia score, muscle mass, body mass index, grip strength, and the number of fractures or injuries at admission.
- * Results indicated that lower skeletal muscle mass index, older age, and weaker grip strength at admission are key predictors of whether a patient will need help with stair climbing upon discharge.
Radio-Tartaglia syndrome (RATARS) (MIM#619312) is a genetic disorder caused by heterozygous truncating variants of SPEN on chromosome 1p36. This syndrome is extremely rare, with only 34 cases reported to date. RATARS is characterized by developmental delay, hypotonia, and intellectual disability.
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- Childhood interstitial lung diseases (chILDs) are serious respiratory disorders with high mortality and significant health issues in children.
- Adult interstitial lung disease classifications do not apply to chILDs, leading to new classifications specifically for children under 2 and those aged 2 to 18.
- The review highlights the different imaging characteristics of chILDs, noting that infantile ILDs have distinct features, whereas pediatric ILDs can resemble adult forms.
Article Synopsis
- The Golgi apparatus is a vital organelle responsible for processing proteins, and this study focused on the distribution of glycosyltransferases within it using advanced imaging techniques.
- Researchers discovered that even glycosyltransferases thought to be in the same compartment have unique localizations influenced by their N-terminal regions.
- The findings suggest that these N-terminal regions are critical for determining where glycosyltransferases are located, enhancing our understanding of Golgi organization and potentially informing clinical strategies for protein glycosylation.