Publications by authors named "E Naschberger"
Secretomes of cancer-associated fibroblasts (CAFs) in colorectal cancer (CRC) contribute to malignancy. Detailed knowledge is available on the components and functions of CAF secretomes. Little is known about the regulation of CAF secretomes.
View Article and Find Full Text PDFTuberculosis (TB) remains one of the top 10 causes of death worldwide and still poses a serious challenge to public health. Recent attention to neutrophils has uncovered unexplored areas demanding further investigation. Therefore, the aim of this study was to determine neutrophil activation and circulatory neutrophil extracellular trap (NET) formation in various types of TB.
View Article and Find Full Text PDFBackground & Aims: Primary sclerosing cholangitis (PSC), often associated with inflammatory bowel disease (IBD), presents a multifactorial etiology involving genetic, immunologic, and environmental factors. Gut dysbiosis and bacterial translocation have been implicated in PSC-IBD, yet the precise mechanisms underlying their pathogenesis remain elusive. Here, we describe the role of gut pathobionts in promoting liver inflammation and fibrosis due to the release of bacterial outer membrane vesicles (OMVs).
View Article and Find Full Text PDFArticle Synopsis
- The vasculature plays a crucial role in solid tumors like colorectal carcinoma (CRC) and is a significant target for therapy, but predicting treatment responses remains a challenge after nearly 20 years of antiangiogenic treatments.
- Resistance to treatment arises due to variations in blood vessel cells, which differ based on species and the specific tumor environment, complicating standardized approaches for all patients.
- Recent discoveries of angiocrine proteins that affect tumor growth and progression highlight new opportunities to improve treatment by normalizing tumor blood vessels and individualized therapy targeting these proteins.