Publications by authors named "E NOVAKOVA"
Article Synopsis
- Endosymbiosis occurs when a microbe lives within a host, playing a key role in the evolution of complex life forms but its transition processes are not well understood.
- The study examines the genus Arsenophonus, revealing that strains shifting from horizontal to vertical transmission have larger genomes due to the acquisition of new genetic features and the loss of defense systems against viral attacks.
- The research suggests that endosymbiosis leads to a mix of genome expansion and eventual reduction as the microbe adapts to its host, enabling rapid genetic innovation before settling into a more stable state.
Article Synopsis
- This study explores the relationship between insects (specifically rodent lice) and bacteria, revealing that different louse species independently acquired Neisseriaceae bacteria likely from the same environmental source.
- Researchers analyzed various microbiomes from three rodent species and identified a Neisseriaceae bacterium in rodent fur that is closely related to louse symbionts.
- The findings suggest that the rodent fur microbiome may facilitate the establishment of new bacterial symbioses in lice, and the study proposes a scenario for how these bacteria evolved from free-living organisms to symbionts.
Aim: To compare the sequences of the tcdC gene between Clostridioides difficile (C. difficile) strains identified as PCR ribotype 176 and the reference strain C. difficile PCR ribotype 027 and to evaluate the use of the Xpert C.
View Article and Find Full Text PDFLimited substrate availability because of the blood-brain barrier (BBB) has made the brain develop specific molecular mechanisms to survive, using lactate synthesized by astrocytes as a source of energy in neurons. To understand if lactate improves cellular viability and susceptibility to glutamate toxicity, primary cortical cells were incubated in glucose- or lactate-containing media and toxic concentrations of glutamate for 24 h. Cell death was determined by immunostaining and lactate dehydrogenase (LDH) release.
View Article and Find Full Text PDFWe present the results of an association study involving hospitalized coronavirus disease 2019 (COVID-19) patients with a clinical background during the 3rd pandemic wave of COVID-19 in Slovakia. Seventeen single nucleotide variants (SNVs) in the eleven most relevant genes, according to the COVID-19 Host Genetics Initiative, were investigated. Our study confirms the validity of the influence of LZTFL1 and 2'-5'-oligoadenylate synthetase (OAS)1/OAS3 genetic variants on the severity of COVID-19.
View Article and Find Full Text PDF