[The level of circulating cytokines and chemokines in the preclinical and early clinical stages of type IA diabetes mellitus development].

Aim: to study the level of circulating proinflammatory (IL-1alpha, IL-1beta, IL-6, alpha-TNF, IFN-gamma) and anti-inflammatory (IL-4, IL-10) cytokines and chemokines (IL-8, IL-16) in preclinical development of type 1A diabetes mellitus (T1DM) in children.

Subjects And Methods: An examination was made in 450 children who had normal blood glucose levels and a burdened history of positive or negative Langerhans islet autoantibodies (LIAA): IAA, GADA, and 1A-2A over time until the clinical manifestations of DM1 emerged. The levels of the cytokines and chemokines were determined by ELISA and the titer of LIAA was by radioimmunoassay.