Influence of Touch-Spun Nanofiber Diameter on Contact Guidance during Peripheral Nerve Repair.

Peripheral nerve regeneration across large gaps remains clinically challenging and scaffold design plays a key role in nerve tissue engineering. One strategy to encourage regeneration has utilized nanofibers or conduits to exploit contact guidance within the neural regenerative milieu. Herein, we report the effect of nanofiber topography on two key aspects of regeneration: Schwann cell migration and neurite extension.

[On the role of psychological disorders in the development of the syndrome of pain dysfunction of the temporomandibular joint].

There are significant disagreements related to the understanding of the etiopathogenesis of the syndrome of pain dysfunction of the temporomandibular joint. This review article examines the role of patient's psychological status as a significant factor influencing the occurrence and complications of this pathology, as evidenced by an increase in stress, anxiety, and depression in patients with the dysfunction. The need for a multidisciplinary and individual approach to the diagnosis and treatment is also discussed, which can significantly alleviate the severity of the disease, reduce complications, and shorten the rehabilitation time.

A Comparative Study on the Effects of High-Intensity Focused Electromagnetic Technology and Electrostimulation for the Treatment of Pelvic Floor Muscles and Urinary Incontinence in Parous Women: Analysis of Posttreatment Data.

Objectives: Pelvic floor muscles (PFMs) weakening and urinary incontinence (UI) represent health issues that have a negative impact on daily life. This study compares the immediate efficiency of high-intensity focused electromagnetic (HIFEM) therapy and electrostimulation for the treatment of weakened PFMs, accompanied by the UI.

Methods: Ninety-five parous women were considered for the study.

Postfabrication Tethering of Molecular Gradients on Aligned Nanofibers of Functional Poly(ε-caprolactone)s.

Substrates with combinations of topographical and biochemical cues are highly useful for a number of fundamental biological investigations. Tethered molecular concentration gradients in particular are highly desired for a number of biomedical applications including cell migration. Herein, we report a versatile method for the fabrication of aligned nanofiber substrates with a tunable concentration gradient along the fiber direction.

RGD-Modified Nanofibers Enhance Outcomes in Rats after Sciatic Nerve Injury.

Nerve injuries requiring surgery are a significant problem without good clinical alternatives to the autograft. Tissue engineering strategies are critically needed to provide an alternative. In this study, we utilized aligned nanofibers that were click-modified with the bioactive peptide RGD for rat sciatic nerve repair.