Publications by authors named "E N Samokhvalova"
Immunogenicity and Protectivity of Sputnik V Vaccine in hACE2-Transgenic Mice against Homologous and Heterologous SARS-CoV-2 Lineages Including Far-Distanced Omicron BA.5.
Vaccines (Basel)
October 2024
Article Synopsis
- The SARS-CoV-2 virus mutates continuously, leading to new variants like Omicron, which has reduced the effectiveness of vaccines worldwide.
- The study evaluated the Sputnik V vaccine's effectiveness against several SARS-CoV-2 variants using various research methods on transgenic mice.
- Results showed that while Sputnik V generates a strong immune response, its efficacy is significantly lower against the Omicron variant, highlighting the need for ongoing monitoring and potential development of new vaccines.
[Prognostic factors of recurrent acute cerebrovascular incidents in patients with ischemic stroke].
Zh Nevrol Psikhiatr Im S S Korsakova
January 2015
Objective: To establish prognostic factors of recurrent acute cerebrovascular complications after ischemic stroke.
Material And Methods: A prospective observational study on the 21-22nd day of the acute stage of ischemic stroke included 148 patients, aged 60 [5; 68] years. Following the discharge, a unified telephone survey of patients or their relatives was performed every 3 months.
The data on the structure of the M genome segment of CCHF virus strains from Russia and Central Asia (Tajikistan) are presented. Data obtained have been compared with other available published sequences of the middle segment of strains from China, Nigeria, and Pakistan. It has been found that all the known strains can be divided into four genetic groups, based on the nucleotide sequence of the M genome segment and an amino acid sequence of the glycoprotein precursor it encodes, whereas VLG/TI29414 and STV/HU29223 strains from Russia form a separate group.
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