[Viferon ointment for prophylaxis of acute viral respiratory tract infection in children].

Three hundred and fifty children at the age of 3 months to 6 years under diverse social conditions were observed in dynamics for the periods of 1 to 3 years. The main tasks of the study were development of schemes and methods for prophylactic use of the Viferon ointment and estimation of its efficacy in acute viral respiratory tract infection. Season changes in the interferon genesis were revealed and no such dynamics in the children with frequent infections was shown.

[The effect of reaferon and alpha-tocopherol on lipid peroxidation in experimental influenza].

Reaferon administered to outbred young mice with experimental influenza had a positive effect on morphologic changes in pulmonary tissues and on lipid peroxidation in the blood plasma and pulmonary tissues. Combined use of reaferon and alpha-tocopherol in mice infected with influenza A virus reduced the mortality rate, boosted the antiviral effect of reaferon proper, and led to virtually complete normalization of lipid peroxidation processes in the blood plasma and pulmonary tissues.

[The natural killer activity and indices of the interferon status of patients with recurrent genital herpes being treated with ridostin].

Natural killer cell activity (NK) in parallel with the interferon (IFN)-alpha and IFN-gamma production as well as with a level of IFN in the blood serum were studied in 15 patients with relapsing herpes genitalis (RHG). Rhidostin, well known as an IFN-alpha inducer, was used in a dose of 2 mg once daily for 3 days subcutaneously up to a total dose of 8 mg of the preparation. The NK cell activity and IFN-alpha production were shown to decrease in RHG more significantly in the stage of remission than during the relapse of the process.

[Potentiation of the antiviral activity of human interferons by virazole in in vitro experiments].

Combination of interferon and virazole results in potentiation of their antiviral activity. This was demonstrated with all three types of natural interferons and the recombinant RL-2-interferon. This effect is retained at a temperature of 37 degrees C and increases when the chemical drug is combined with a mixture of alpha- and gamma-interferon.

[Formation of an acid-labile interferon induced in human leukocytes by the influenza virus].

Predominantly acid-labile interferon was produced by treatment with influenza virus (inducer) of a portion of leukocytes followed by their addition to the main cell pool. This interferon could be detected by treatment of the material with antiserum to the inducer virus and ultracentrifugation. This treatment completely eliminated the activity of the virus-inducer present in the material.