[Neuroprotector therapy of patients with decompensated diabetes mellitus type 1].

The influence of actovegin and reamberin on diabetic ketoacidotic crises has been studied on a group of 128 patients with severe diabetic ketoacidosis on the background of diabetes mellitus type 1 with disorders ranging from consciousness to coma or precoma states. Patients of group 1 received standard intensive therapy of diabetic ketoacidosis. In group 2, an intensive therapy for neuroprotection by actovegin was added.

[The use of perftoran in patients with burn shock].

Basing on studying of the biogenic amines metabolism and indexes of cardiodynamics in 49 patients with the burn shock of middle severity it was established, that performance of single infusion of perftoran preparation in the first day of the burn trauma had stimulated the organism adaptation reconstruction due to demolition of the catecholamines metabolism dysbalance, prevalence of stress-limiting processes in the reply to stress structure, formation of moderate hyperdynamics of blood circulation. The double infusion of the preparation had permitted to guarantee the indexes stabilization during all acute period of the burn disease.

[Biogenic amine metabolism in severe brain trauma during various techniques of brain protection from hypoxia].

Biogenic amine metabolism in severe brain trauma has been analysed in 165 patients whose brain was protected from hypoxia with GOBA and thiobarbiturates in subnarcotic doses (116 cases) and the combination of the above agents with an early course of HBO (49 cases). The peculiarities of biogenic amine metabolism have been established in patients recovered and those who died later. As any activation of biogenic amine systems realizing stress enhances disadaptation processes, it is recommended to begin a course of HBO upon their stabilization.

[Hyperbaric oxygenation and adaptation to severe craniocerebral trauma].

Adaptation and disadaptation processes predetermining the outcome of treatment have been revealed upon the analysis of adaptation mechanisms formed in 49 patients with severe craniocerebral trauma in conditions of brain protection from hypoxia achieved by combined bolus injection of subnarcotic doses of sodium hydroxybutyrate and sodium thiopental and an early course of hyperbaric oxygenation (HBO). As the activation of biogenic amine systems responsible for stress promotes the enhancement of disadaptation processes, it is recommended to start a course of HBO upon their stabilization. The nature of lactate and pyruvate level changes in the in- and outflowing blood enabled the authors to identify the presence of negative arteriovenous difference in pyruvate upon the first attempt of HBO session as an adaptation marker and biochemical criterion showing the advisability of an HBO course.